Wong Z Y, Tsonis D, van Herwerden L, Raven J, Forbes A, Abramson M J, Walters E H, Harrap S B
Department of Physiology, University of Melbourne, Parkville, Victoria, Australia.
Electrophoresis. 1997 Aug;18(9):1641-5. doi: 10.1002/elps.1150180928.
There are two key clinical features of asthma: allergy and bronchial hyperreactivity (BHR). Some pedigree studies of atopy have indicated linkage with the high affinity IgE receptor (Fc epsilon RI-beta) gene on chromosome 11q13, but others failed to confirm this linkage. We examined the genetic linkage of three polymorphic microsatellite markers to atopy and BHR in 120 affected sibling pairs recruited from the general community. We found no linkage to atopy at any of the three 11q13 loci studied. Our findings also do not favour linkage between BHR and loci approximately 8-9 cM either side of the Fc epsilon RI-beta gene.
过敏和支气管高反应性（BHR）。一些关于特应性的家系研究表明与11q13染色体上的高亲和力IgE受体（FcεRI-β）基因存在连锁关系，但其他研究未能证实这种连锁。我们在从普通人群中招募的120对患病同胞对中，研究了三个多态性微卫星标记与特应性和BHR的遗传连锁。在研究的三个11q13位点中的任何一个位点，我们都未发现与特应性的连锁关系。我们的研究结果也不支持BHR与FcεRI-β基因两侧约8-9 cM的位点之间存在连锁关系。
