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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Gaggi R, Dall' Olio R, Santangelo M, Roncada P

Department of Pharmacology, University of Bologna, Italy.

Gen Pharmacol. 1997 Sep;29(3):415-9. doi: 10.1016/s0306-3623(96)00484-3.

The effects of the serotonin (5-HT) precursor, L-5-hydroxytryptophan (L-5-HTP), or the selective 5-HT1A receptor agonist, 8-OHDPAT, on behavior or brain 5-HT metabolism or both were evaluated in rats IP pretreated with nimodipine at doses ranging from 0.31 to 40 mg/kg. 2. Nimodipine, in a wide dose range (0.6-20.0 mg/kg) potentiated the head-twitch response to L-5-HTP. 3. The effects of nimodipine on the 5-HT metabolism of rats treated with L-5-HTP did not comply with the increase in the behavioral response to this 5-HT precursor. 4. Nimodipine antagonized the effects on 5-HT metabolism induced by 8-hydroxy-2-(di-N-propyl-amino)-tetralin through stimulation of 5-HT1A autoreceptors. 5. It was concluded that the effects of nimodipine on brain 5-HT metabolism appeared to be linked to activation of serotonergic neurotransmission likely due to inhibition of the back-regulation mechanism mediated by presynaptic 5-HT1A receptors.

在以0.31至40mg/kg剂量腹腔注射尼莫地平预处理的大鼠中，评估了血清素（5-羟色胺，5-HT）前体L-5-羟色氨酸（L-5-HTP）或选择性5-HT1A受体激动剂8-OHDPAT对行为或脑5-HT代谢或两者的影响。2. 在宽剂量范围（0.6-20.0mg/kg）内，尼莫地平增强了对L-5-HTP的头部抽搐反应。3. 尼莫地平对接受L-5-HTP治疗的大鼠5-HT代谢的影响与对该5-HT前体行为反应的增加不一致。4. 尼莫地平通过刺激5-HT1A自身受体拮抗8-羟基-2-（二-N-丙基-氨基）-四氢萘对5-HT代谢的影响。5. 得出的结论是，尼莫地平对脑5-HT代谢的影响似乎与血清素能神经传递的激活有关，这可能是由于抑制了由突触前5-HT1A受体介导的反向调节机制。

Gaggi R, Dall' Olio R, Santangelo M, Roncada P

Department of Pharmacology, University of Bologna, Italy.

Gen Pharmacol. 1997 Sep;29(3):415-9. doi: 10.1016/s0306-3623(96)00484-3.

The effects of the serotonin (5-HT) precursor, L-5-hydroxytryptophan (L-5-HTP), or the selective 5-HT1A receptor agonist, 8-OHDPAT, on behavior or brain 5-HT metabolism or both were evaluated in rats IP pretreated with nimodipine at doses ranging from 0.31 to 40 mg/kg. 2. Nimodipine, in a wide dose range (0.6-20.0 mg/kg) potentiated the head-twitch response to L-5-HTP. 3. The effects of nimodipine on the 5-HT metabolism of rats treated with L-5-HTP did not comply with the increase in the behavioral response to this 5-HT precursor. 4. Nimodipine antagonized the effects on 5-HT metabolism induced by 8-hydroxy-2-(di-N-propyl-amino)-tetralin through stimulation of 5-HT1A autoreceptors. 5. It was concluded that the effects of nimodipine on brain 5-HT metabolism appeared to be linked to activation of serotonergic neurotransmission likely due to inhibition of the back-regulation mechanism mediated by presynaptic 5-HT1A receptors.

在以0.31至40mg/kg剂量腹腔注射尼莫地平预处理的大鼠中，评估了血清素（5-羟色胺，5-HT）前体L-5-羟色氨酸（L-5-HTP）或选择性5-HT1A受体激动剂8-OHDPAT对行为或脑5-HT代谢或两者的影响。2. 在宽剂量范围（0.6-20.0mg/kg）内，尼莫地平增强了对L-5-HTP的头部抽搐反应。3. 尼莫地平对接受L-5-HTP治疗的大鼠5-HT代谢的影响与对该5-HT前体行为反应的增加不一致。4. 尼莫地平通过刺激5-HT1A自身受体拮抗8-羟基-2-（二-N-丙基-氨基）-四氢萘对5-HT代谢的影响。5. 得出的结论是，尼莫地平对脑5-HT代谢的影响似乎与血清素能神经传递的激活有关，这可能是由于抑制了由突触前5-HT1A受体介导的反向调节机制。