新型皮啡肽类似物Tyr-D-Arg-Phe-β-Ala-NH2对小鼠高架十字迷宫学习及自发交替行为表现的影响

Effects of Tyr-D-Arg-Phe-beta-Ala-NH2, a novel dermorphin analog, on elevated plus-maze learning and spontaneous alternation performance in mice.

Ukai M, Monma J, Shinkai N, Sasaki Y, Kameyama T

Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.

Gen Pharmacol. 1997 Sep;29(3):453-6. doi: 10.1016/s0306-3623(96)00483-1.

Abstract

The effects of intracerebroventricular administration of Tyr-D-Arg-Phe-beta-Ala-NH2 (TAPA), a novel dermorphin analog, on plus-maze learning and spontaneous alternation performance were investigated in mice. 2. The pre- or posttraining or preretention administration of TAPA (0.3-3.0 ng) alone failed to affect transfer latency of plus-maze learning, whereas TAPA (3 ng) produced a significant decrease in percent alternation without affecting total arm entries. 3. beta-Funaltrexamine (5 micrograms) almost completely reversed the TAPA (3 ng)-induced decrease in percentage of alternation. 4. These results suggest that stimulation of mu-opioid receptors disrupts spontaneous alternation performance associated with spatial working memory.

摘要

研究了新型强啡肽类似物酪氨酰-D-精氨酰-苯丙氨酰-β-丙氨酸-酰胺（TAPA）脑室内给药对小鼠在加迷宫学习及自发交替行为表现的影响。2. 单独给予TAPA（0.3 - 3.0纳克）进行训练前、训练后或记忆保持前给药，均未影响加迷宫学习的转移潜伏期，而TAPA（3纳克）可使交替百分比显著降低，且不影响进入总臂数。3. β-芬基曲胺（5微克）几乎完全逆转了TAPA（3纳克）诱导的交替百分比下降。4. 这些结果表明，μ-阿片受体的激活会破坏与空间工作记忆相关的自发交替行为表现。