Boev V M, Nikonorov A A, Perepelkin S V, Filippov V K
Gig Sanit. 1997 Sep-Oct(5):5-6.
Chronic action of different xenobiotics which form a part of condensed hydrogen sulphide-containing gas causes substantial changes in the activity of xenobiotic metabolic enzymes, which is suggestive of the damaged hepatic microsomal monooxygenase system. As the rate of biotransformation becomes higher, there are increases in the activity of microsomal monooxygenases and in the generation of active oxygen forms and hydrogen peroxide, by impairing antiradical and antiperoxide mechanisms. The experimentally used concentration of substances as constituents of condensed gas corresponds to the maximum acceptable air concentration of in the working area of gas-refining plants, but the functional features of the body's detoxifying system--the hepatic monooxygenase system should be taken into account while developing preventive measures of occupational diseases.
构成含硫化氢冷凝气体一部分的不同外源性物质的慢性作用，会导致外源性物质代谢酶活性发生显著变化，这表明肝微粒体单加氧酶系统受损。随着生物转化速率升高，微粒体单加氧酶活性以及活性氧形式和过氧化氢的生成都会增加，这是由于抗自由基和抗过氧化物机制受到损害。实验中使用的作为冷凝气体成分的物质浓度，相当于气体精炼厂工作区域空气中的最大可接受浓度，但在制定职业病预防措施时，应考虑人体解毒系统——肝单加氧酶系统的功能特性。
