Lee A M, Knoll J L, Suppes T
Mental Health Connections Research, Dallas, Texas, USA.
J Clin Psychiatry. 1997 Sep;58(9):410-6; quiz 417-8. doi: 10.4088/jcp.v58n0908.
Psychotic disorders are often difficult to treat with traditional neuroleptics. Sertindole is a new atypical neuroleptic with a broader CNS receptor profile.
Ten patients diagnosed with either schizophrenia or schizoaffective disorder were treated with sertindole for 18 months and observed for changes in Clinical Global Impression scale scores.
Nine patients experienced a reduction of symptoms after 12 months of treatment. Eight patients completed 18 months of treatment, all exhibiting overall improvement. Despite side effects of tiredness, weight gain, headache, nausea, and decreased ejaculatory volume, sertindole was generally well tolerated.
Sertindole appears to be a useful treatment in psychotic disorders. It may present an advantage over traditional neuroleptics in the form of fewer extrapyramidal symptoms and improvement of negative symptoms.
精神障碍通常难以用传统抗精神病药物治疗。舍吲哚是一种新型非典型抗精神病药物，对中枢神经系统受体具有更广泛的作用谱。
10名被诊断为精神分裂症或分裂情感性障碍的患者接受舍吲哚治疗18个月，并观察临床总体印象量表评分的变化。
9名患者在治疗12个月后症状减轻。8名患者完成了18个月的治疗，均表现出总体改善。尽管有疲劳、体重增加、头痛、恶心和射精量减少等副作用，但舍吲哚总体耐受性良好。
舍吲哚似乎是治疗精神障碍的一种有效药物。它可能比传统抗精神病药物具有优势，表现为锥体外系症状较少且阴性症状得到改善。
