Crawford B A, Harewood W J, Handelsman D J
Department of Medicine, University of Sydney, NSW.
J Med Primatol. 1997 Jun;26(3):153-63. doi: 10.1111/j.1600-0684.1997.tb00047.x.
The semi-longitudinal collection of growth measurements in male and female hamadryas baboons has enabled documentation of the timing of puberty and the development of sexually dimorphic growth patterns in body weight, crown-rump length (CRL), limb lengths, and muscle mass. In addition, another sexually dimorphic characteristic appears to be the presence of a pubertal growth spurt in body weight, and possibly CRL, in male but not female baboons. Serum testosterone levels rose during male development; however, there was a progressive decrease in dehydroepiandrosterone sulfate levels indicating the absence of adrenarche. Insulin-like growth factor-I (IGF-I) and its major binding protein, IGFBP-3, both rose during pubertal development; however, a simultaneous rise in the IGF-I:IGFBP-3 molar ratio suggests other factors may enhance the bioactivity of IGF-I during puberty. A distinct rise in serum osteocalcin levels was also associated with puberty in male baboons. These growth and hormonal changes during puberty in the hamadryas baboon indicate that this species provides a close primate model for human puberty.
对雄性和雌性阿拉伯狒狒生长测量的半纵向收集，使得记录青春期时间以及体重、顶臀长（CRL）、肢体长度和肌肉量等性二态生长模式的发育情况成为可能。此外，另一个性二态特征似乎是，雄性阿拉伯狒狒在体重以及可能在CRL方面出现青春期生长突增，而雌性则没有。雄性发育过程中血清睾酮水平升高；然而，硫酸脱氢表雄酮水平逐渐下降，表明肾上腺功能初现缺失。胰岛素样生长因子-I（IGF-I）及其主要结合蛋白IGFBP-3在青春期发育过程中均升高；然而，IGF-I:IGFBP-3摩尔比同时升高表明，青春期可能有其他因素增强IGF-I的生物活性。血清骨钙素水平明显升高也与雄性阿拉伯狒狒的青春期有关。阿拉伯狒狒青春期的这些生长和激素变化表明，该物种为人类青春期提供了一个相近的灵长类动物模型。
