Bernardczyk-Meller J, Galas-Zgorzalewicz B, Gradzki J, Meller M, Paprzycki W, Toczko A, Załecki K, Zgorzalewicz M
Kliniki Okulistycznej AM w Poznaniu.
Klin Oczna. 1997;99(1):43-6.
To evaluate the sensitivity of various diagnostic methods in the optic neuritis.
15 patients, 10 boys and 5 girls, aged 6-18 years, with optic neuritis have been examined. Multiple sclerosis was diagnosed in 12 cases, the etiology of 3 was unknown. The full ophthalmological examination, including static perimetry and visual evoked potentials (VEP) as well as brain computed tomography (CT) and magnetic resonance imaging (MRI) were performed.
MRI revealed plaques of demyelination in 11 patients; no pathological changes were observed in cases of idiopathic neuritis. In CT plaques of demyelination were found in 2 patients only. In most cases VEPs were abnormal, mainly there was prolonged latency of deflection, decreased amplitude and more rarely changes of the shape of the record. Static perimetry, with white and blue target, revealed multiple scattered absolute and relative scotoma in the 30 degrees central area.
MRI and static perimetry were the most sensitive methods for detection of the changes in optic neuritis and these methods are also useful in cases with asymptomatic involvement of visual pathway, especially in multiple sclerosis.
评估各种诊断方法对视神经炎的敏感性。
对15例年龄在6至18岁的视神经炎患者进行了检查，其中10例为男孩，5例为女孩。12例诊断为多发性硬化症，3例病因不明。进行了全面的眼科检查，包括静态视野检查和视觉诱发电位（VEP），以及脑部计算机断层扫描（CT）和磁共振成像（MRI）。
11例患者MRI显示脱髓鞘斑块；特发性神经炎患者未观察到病理变化。CT仅在2例患者中发现脱髓鞘斑块。大多数情况下VEP异常，主要表现为波峰潜伏期延长、波幅降低，形状改变较少见。使用白色和蓝色视标进行的静态视野检查显示，在中心30度区域有多个散在的绝对和相对暗点。
MRI和静态视野检查是检测视神经炎变化最敏感的方法，这些方法对于视觉通路无症状受累的病例也很有用，尤其是在多发性硬化症中。
