Tateno S, Kobayashi Y, Robinson D R
Department of Medicine, Kitasato University School of Medicine, Kanagawa, Japan.
Nephron. 1997;77(1):86-92. doi: 10.1159/000190251.
The effects of fish oil (FO) on immune complex nephritis induced by bovine serum albumin (BSA) were studied in female B10.Br mice. The mice were fed an experimental fat-free diet composed of either 10% FO, safflower oil (SO), or beef tallow (BT) as a lipid source throughout the study. Proteinuria was observed in 84% of the FO group (n = 19), 53% of the SO group (n = 19) and in 48% of the BT group (n = 19; p = 0.0217 vs. FO). The FO group showed a tendency toward more severe renal histologic changes than the SO and BT groups. The levels of anti-BSA antibody and circulating BSA-anti-BSA immune complexes were significantly higher in the FO group than in the SO and in the BT groups. Avidity of the anti-BSA antibodies showed a lower tendendy in the FO group. Prostaglandin E2 and thromboxane B2 productions by the renal cortex were much lower in the FO than in the other two groups. The ratios thromboxane B2/prostaglandin E2 were higher in the FO than in the BT group. These results suggest that FO oil supplementation leads to the deterioration of BSA-induced immune complex nephritis in mice due to the altered immune responses in association with suppressed prostanoid production.
在雌性B10.Br小鼠中研究了鱼油（FO）对牛血清白蛋白（BSA）诱导的免疫复合物性肾炎的影响。在整个研究过程中，给小鼠喂食由10%的FO、红花油（SO）或牛脂（BT）作为脂质来源组成的无脂实验饮食。FO组84%（n = 19）、SO组53%（n = 19）和BT组48%（n = 19）出现蛋白尿（与FO组相比，p = 0.0217）。与SO组和BT组相比，FO组的肾脏组织学变化有更严重的趋势。FO组抗BSA抗体和循环BSA-抗BSA免疫复合物水平显著高于SO组和BT组。FO组抗BSA抗体的亲和力呈较低趋势。FO组肾皮质中前列腺素E2和血栓素B2的产生远低于其他两组。FO组血栓素B2/前列腺素E2的比值高于BT组。这些结果表明，补充FO油会导致小鼠中BSA诱导的免疫复合物性肾炎恶化，这是由于免疫反应改变以及前列腺素生成受抑制所致。
