Vámos A, Balázs C
Kenézy Gyula Kórház, III. Belgyógyászat Debrecen.
Orv Hetil. 1997 Sep 21;138(38):2403-5.
Collagen type I is the main collagen type found in bones. Carboxyterminal propeptide, deriving and cleaved from procollagen type I (PICP) during collagen synthesis, is delivered into the blood, where it might represent an useful marker of bone formation similarly to osteocalcin. PICP, osteocalcin, alkaline phosphatase, serum and urinary calcium excretion were measured in 58 premenopausal females affected by Graves' disease and also 28 of them after attainment of euthyroidism by methimazole treatment to study these biochemical indices of bone remodelling before and after treatment. Before therapy PICP (mean +/- S.D.: 244.2 +/- 112.3 vs. 136.8 +/- 32.4 micrograms/l), osteocalcin (mean +/- S.D.: 17.8 +/- 6.7 vs. 7.5 +/- 2.7 micrograms/l) and other markers were significantly (p < 0.05) higher than sex and age matched controls (n = 24). Treatment induced a significant decrease of PICP, alkaline phosphatase, calcaemia and calciuria compared to pretreatment values, while osteocalcin did not significantly differ (mean +/- S. D.: 17.8 +/- 6.7 vs. 14.7 +/- 8.7 micrograms/l). These data suggest that hyperthyroidism due to Graves' disease causes an increase of serum levels of these markers, but further studies are necessary to asses the differences between PICP and osteocalcin as markers of osteoblast activity in hyperthyroidism.
I型胶原蛋白是骨骼中主要的胶原蛋白类型。在胶原蛋白合成过程中，从I型前胶原衍生并裂解而来的羧基末端前肽被释放到血液中，它可能像骨钙素一样是骨形成的有用标志物。对58名患有格雷夫斯病的绝经前女性以及其中28名经甲巯咪唑治疗达到甲状腺功能正常后的女性，测定了PICP、骨钙素、碱性磷酸酶、血清和尿钙排泄量，以研究治疗前后这些骨重塑的生化指标。治疗前，PICP（均值±标准差：244.2±112.3 vs. 136.8±32.4微克/升）、骨钙素（均值±标准差：17.8±6.7 vs. 7.5±2.7微克/升）和其他标志物显著（p<0.05）高于性别和年龄匹配的对照组（n = 24）。与治疗前值相比，治疗导致PICP、碱性磷酸酶、血钙和尿钙显著降低，而骨钙素无显著差异（均值±标准差：17.8±6.7 vs. 14.7±8.7微克/升）。这些数据表明，格雷夫斯病引起的甲状腺功能亢进导致这些标志物的血清水平升高，但需要进一步研究以评估PICP和骨钙素作为甲状腺功能亢进中成骨细胞活性标志物的差异。
