Bangsbøll S
Gynaekologisk-obstetrisk afdeling G, Amtssygehuset i Herlev.
Nord Med. 1997 Sep;112(7):236-9.
Ovarian hyperstimulation syndrome (OHSS), a potential life-threatening condition the causative factor of which is unknown, comprises a spectrum of clinical symptoms and laboratory signs. The main risk factors for the development of OHSS include inherent ovarian sensitivity to ovulation induction agents, the use of exogenous hCG (human chorionic gonadotrophin) for ovulation induction or luteal phase support, and endogenous hCG production in early pregnancy. Since assisted reproduction entails achieving a delicate balance between controlled ovarian stimulation and hyperstimulation, complete elimination of the risk of OHSS is unlikely. However, it seems possible to reduce the frequency of severe cases by observing strict rules for its prediction and prevention, allowing early diagnosis and active treatment of manifest OHSS by correction of fluid and electrolyte imbalance, and aspiration of ascitic fluid if necessary.
卵巢过度刺激综合征（OHSS）是一种潜在的危及生命的疾病，其病因不明，包括一系列临床症状和实验室指标。OHSS发生的主要危险因素包括卵巢对促排卵药物固有的敏感性、使用外源性人绒毛膜促性腺激素（hCG）进行促排卵或黄体期支持以及孕早期内源性hCG的产生。由于辅助生殖需要在控制性卵巢刺激和过度刺激之间实现微妙的平衡，因此完全消除OHSS的风险不太可能。然而，通过遵守严格的预测和预防规则，似乎有可能降低严重病例的发生率，通过纠正液体和电解质失衡对明显的OHSS进行早期诊断和积极治疗，并在必要时抽吸腹水。
