Dale R C, Schroeder E T
Arch Intern Med. 1976 Jul;136(7):816-8.
Four cases are reported in which respiratory arrest occured coincident with the intravenous administration of large doses of trimethaphan camsylate (Arfonad) to control hypertension. The mechanism of the respiratory depression is unknown, but it may have been related to a direct effect of trimethaphan on the respiratory center or to a curare-like effect of the drug. Close monitoring of ventilatory capacity should be maintained in all patients treated with trimethaphan.
报告了4例在静脉注射大剂量樟磺咪芬（阿方那特）以控制高血压时发生呼吸骤停的病例。呼吸抑制的机制尚不清楚，但可能与樟磺咪芬对呼吸中枢的直接作用或该药物的箭毒样作用有关。在用樟磺咪芬治疗的所有患者中，应密切监测通气能力。
