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[硬膜外使用吗啡和α2激动剂用于术后镇痛]

[The epidural use of morphine and alpha 2-agonists for postoperative analgesia].

作者信息

Dobrydnev I, Samariutel' Iu

出版信息

Anesteziol Reanimatol. 1997 Jul-Aug(4):7-11.

PMID:9382235
Abstract

Three protocols of postoperative pain relief after gastric surgery were used in 60 male patients: regular intramuscular morphine, epidural morphine, and epidural morphine with 0.1 mg of clonidine. Pain relief was more effective with the epidural route of administration. Addition of clonidine in a daily dose of 0.1 mg allowed a twofold decrease of epidural morphine dose, involving lesser hyperdynamic postoperative cardiovascular changes and complete elimination of psychotic complications and delirium in alcohol-dependent patients.

摘要

60名男性患者在胃手术后采用了三种术后疼痛缓解方案：常规肌肉注射吗啡、硬膜外注射吗啡以及硬膜外注射含0.1毫克可乐定的吗啡。硬膜外给药途径的止痛效果更佳。每日剂量为0.1毫克的可乐定可使硬膜外吗啡剂量减少一半，减少术后心血管高动力变化，并完全消除酒精依赖患者的精神并发症和谵妄。

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