非裔美国人中载脂蛋白E与阿尔茨海默病的关联风险取决于基因型。

Apolipoprotein E-associated risk for Alzheimer's disease in the African-American population is genotype dependent.

作者信息

Sahota A, Yang M, Gao S, Hui S L, Baiyewu O, Gureje O, Oluwole S, Ogunniyi A, Hall K S, Hendrie H C

机构信息

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202-5111, USA.

出版信息

Ann Neurol. 1997 Oct;42(4):659-61. doi: 10.1002/ana.410420418.

DOI:10.1002/ana.410420418

PMID:9382479

Abstract

As a part of our ongoing study on Alzheimer's disease (AD) in elderly African Americans, we obtained clinical assessment and apolipoprotein E (ApoE) genotype data on 288 individuals (including 60 with AD). The ApoE epsilon4 allele frequency was significantly increased in AD patients compared with controls. The age-adjusted odds ratio (OR) for AD in epsilon4 homozygotes was 4.83 (95% confidence interval [CI], 1.71-13.64) compared with the epsilon3/epsilon3 genotype, but the OR for AD with the epsilon3/epsilon4 genotype did not reach significance (1.20; 95% CI, 0.58-2.45). These findings suggest that the association between ApoE epsilon4 and AD is weaker in African Americans than in whites.

摘要

作为我们对老年非裔美国人阿尔茨海默病（AD）持续研究的一部分，我们获取了288名个体（包括60名AD患者）的临床评估和载脂蛋白E（ApoE）基因型数据。与对照组相比，AD患者中ApoE ε4等位基因频率显著增加。与ε3/ε3基因型相比，ε4纯合子中AD的年龄调整优势比（OR）为4.83（95%置信区间[CI]，1.71 - 13.64），但ε3/ε4基因型的AD的OR未达到显著水平（1.20；95% CI，0.58 - 2.45）。这些发现表明，ApoE ε4与AD之间的关联在非裔美国人中比在白人中更弱。