Rubio-Briones J, Villavicencio H, Regalado R, Chéchile G, Algaba F, Monreal F, Lee S J, Palou J, Vicente J
Servicio de Urología y de Anatomía Patológica, Fundación Puigvert, Barcelona, España.
Arch Esp Urol. 1997 Jun;50(5):473-80.
The management of lymph nodes and the determination of prognostic factors are matters of controversy in the treatment of squamous cell carcinoma of the penis. We attempted to establish an approach based on the different types of lymphadenectomies and biopsies we have performed and to evaluate local stage and grade of cellular differentiation as prognostic factors.
81 cases treated at our institution between 1980 and 1994 were reviewed. The results of the different lymphadenectomies and biopsies performed were analyzed. Tumors were staged according to the Jackson and TNM classifications; in 62 cases the pathological samples were reexamined by the same pathologist to determine the grade of cellular differentiation according to the Broders classification. A p value of < 0.05 was considered significant.
We did not obtain reliable results with the biopsies done and variable results in the lymphadenectomies performed. The grade of cellular differentiation and local stage were both statistically significant with respect to the presence of positive lymph nodes. We found statistically significant differences for survival according to the stage of the positive lymph nodes.
We have established three approaches in management of squamous cell carcinoma of the penis according to the local stage and grade of cellular differentiation.
在阴茎鳞状细胞癌的治疗中，淋巴结的处理及预后因素的判定存在争议。我们试图基于所施行的不同类型的淋巴结切除术和活检建立一种方法，并评估局部分期及细胞分化程度作为预后因素。
回顾了1980年至1994年间在我院治疗的81例病例。分析了所施行的不同淋巴结切除术和活检的结果。肿瘤根据杰克逊和TNM分类进行分期；62例病例的病理样本由同一位病理学家重新检查，以根据布罗德斯分类确定细胞分化程度。p值<0.05被认为具有显著性。
我们所做的活检未获得可靠结果，所施行的淋巴结切除术结果也各不相同。细胞分化程度和局部分期在淋巴结阳性方面均具有统计学显著性。我们发现根据阳性淋巴结的分期，生存率存在统计学显著性差异。
我们根据局部分期和细胞分化程度建立了阴茎鳞状细胞癌的三种处理方法。
