Dorandeu A, Chrétien F, Dubreuil-Lemaire M L, Flament-Saillour M, De Truchis P, Durigon M, Gray F
Service d'Anatomie Pathologique, Faculté de Médecine Paris-Ouest, Hôpital R. Poincaré, Garches, France.
Arch Anat Cytol Pathol. 1997;45(2-3):121-6.
Fungal infections of the central nervous system are uncommon in human immunodeficiency virus infected patients. The most frequently encountered is cerebromeningeal cryptococcosis. We report 3 clinicopathological cases of rarer fungal infections of the central nervous system in AIDS patients due to Candida and Aspergillus genders. In most cases, a systemic candida infection or aspergillus pulmonary infection preceded the onset of cerebral granulomas or abscesses. These infections usually occurred at the terminal stage of the disease and were associated with other neuropathologies. Neutropenia associated with lymphopenia represents a frequent risk factor along with intravenous catheter.
中枢神经系统真菌感染在人类免疫缺陷病毒感染患者中并不常见。最常遇到的是脑脊髓膜隐球菌病。我们报告了3例艾滋病患者因念珠菌和曲霉菌属导致的罕见中枢神经系统真菌感染的临床病理病例。在大多数情况下，系统性念珠菌感染或曲霉菌性肺部感染先于脑肉芽肿或脓肿的发作。这些感染通常发生在疾病的终末期，并与其他神经病理学相关。与淋巴细胞减少相关的中性粒细胞减少与静脉导管一样是常见的危险因素。
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