Wrzolek M A, Brudkowska J, Kozlowski P B, Rao C, Anzil A P, Klein E A, Del Rosario C, Abdu A, Kaufman L, Chandler F W
Department of Pathology, State University of New York Health Science Center, Brooklyn 11203, USA.
Clin Neuropathol. 1995 Jul-Aug;14(4):187-96.
Central nervous system (CNS) abnormalities attributed to direct effects of HIV infection are seen in most of children with acquired immunodeficiency syndrome (AIDS). Secondary CNS infections with opportunistic and common pathogens are infrequent in this age group. We report 9 cases of opportunistic infection of the CNS found among 65 autopsy cases of pediatric AIDS. These included 4 cases of cytomegalovirus (CMV) infection, 1 of which was associated with aspergillosis, and 2 cases of candidiasis, 1 of which coexisted with Mycobacterium avium intracellulare (MAI) infection. There were also 2 cases of leptomeningitis, 1 due to Mycobacterium tuberculosis (MTB) and the other to Cryptococcus neoformans. In 1 child progressive multifocal leukoencephalopathy (PML) coexisted with mycotic encephalitis caused by an Aspergillus sp.
大多数获得性免疫缺陷综合征（AIDS）患儿都存在归因于HIV感染直接影响的中枢神经系统（CNS）异常。该年龄组中继发于机会性和常见病原体的中枢神经系统感染并不常见。我们报告了在65例儿科AIDS尸检病例中发现的9例中枢神经系统机会性感染。其中包括4例巨细胞病毒（CMV）感染，其中1例与曲霉菌病相关，2例念珠菌病，其中1例与细胞内鸟分枝杆菌（MAI）感染共存。还有2例柔脑膜脑膜炎，1例由结核分枝杆菌（MTB）引起，另1例由新型隐球菌引起。在1名儿童中，进行性多灶性白质脑病（PML）与由曲霉菌属引起的霉菌性脑炎共存。
