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特发性骨化三醇诱导的高钙血症。一种新的疾病实体?

Idiopathic calcitriol-induced hypercalcemia. A new disease entity?

作者信息

Evron E, Goland S, von der Walde J, Schattner A, Sthoeger Z M

机构信息

Division of Internal Medicine, Kaplan Hospital, Rehovot, Israel.

出版信息

Arch Intern Med. 1997 Oct 13;157(18):2142-5.

PMID:9382671
Abstract

We describe 3 patients with a prolonged history of hypercalcemia. The patients did not take any vitamin supplements. All patients had low parathyroid hormone (PTH), high calcitriol (1,25(OH)2D3), and high angiotensin-converting enzyme (ACE) blood levels. There was no evidence of sarcoidosis of any other underlying disease in the results of an extensive workup. Treatment with prednisone resulted in normalization of calcium levels in all patients. They remained dependent on low-dose prednisone on a subsequent prolonged follow-up.

摘要

我们描述了3例有长期高钙血症病史的患者。这些患者未服用任何维生素补充剂。所有患者的甲状旁腺激素(PTH)水平低、骨化三醇(1,25(OH)₂D₃)水平高、血管紧张素转换酶(ACE)血液水平高。全面检查结果未发现任何其他潜在疾病的结节病证据。泼尼松治疗使所有患者的钙水平恢复正常。在随后的长期随访中,他们仍依赖小剂量泼尼松。

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