微管动力学：瞄准移动目标
Microtubule dynamics: taking aim at a moving target.
作者信息
Wilson L, Jordan M A
机构信息
Department of Molecular, Cellular & Developmental Biology, University of California, Santa Barbara 93106-9610, USA.
出版信息
Chem Biol. 1995 Sep;2(9):569-73. doi: 10.1016/1074-5521(95)90119-1.
PMID:9383460
Abstract
Antitumor drugs of the vinca alkaloid and taxane classes function by suppressing the dynamics of microtubules in spindles, blocking cell division at metaphase. The drugs bind to various sites on the tubulin dimer and at different positions within the microtubule, suggesting that there are many unexplored targets for the design of novel drugs of this type.
摘要
长春花生物碱类和紫杉烷类抗肿瘤药物通过抑制纺锤体中微管的动态变化发挥作用，在中期阻断细胞分裂。这些药物与微管蛋白二聚体上的不同位点以及微管内的不同位置结合，这表明这类新型药物的设计存在许多未被探索的靶点。
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