纤维衍生的丁酸盐与结肠癌的预防
Fiber-derived butyrate and the prevention of colon cancer.
作者信息
Hassig C A, Tong J K, Schreiber S L
机构信息
Howard Hughes Medical Institute, Harvard University, Department of Chemistry, Cambridge, MA 02138, USA. hassig@slsiris. harvard.edu
出版信息
Chem Biol. 1997 Nov;4(11):783-9. doi: 10.1016/s1074-5521(97)90111-3.
PMID:9384528
Abstract
Inhibition of the enzyme histone deacetylase by butyrate results in the direct transcriptional upregulation of the cyclin-dependent kinase inhibitor p21/Cip1/WAF1. We discuss a small-molecule-mediated signaling pathway to explain the suspected anti-colon-cancer properties of fiber-derived butyrate.
摘要
丁酸盐对组蛋白脱乙酰酶的抑制作用导致细胞周期蛋白依赖性激酶抑制剂p21/Cip1/WAF1的直接转录上调。我们讨论了一种小分子介导的信号通路，以解释纤维衍生的丁酸盐疑似的抗结肠癌特性。
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