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纤维衍生的丁酸盐与结肠癌的预防

Fiber-derived butyrate and the prevention of colon cancer.

作者信息

Hassig C A, Tong J K, Schreiber S L

机构信息

Howard Hughes Medical Institute, Harvard University, Department of Chemistry, Cambridge, MA 02138, USA. hassig@slsiris. harvard.edu

出版信息

Chem Biol. 1997 Nov;4(11):783-9. doi: 10.1016/s1074-5521(97)90111-3.

DOI:10.1016/s1074-5521(97)90111-3
PMID:9384528
Abstract

Inhibition of the enzyme histone deacetylase by butyrate results in the direct transcriptional upregulation of the cyclin-dependent kinase inhibitor p21/Cip1/WAF1. We discuss a small-molecule-mediated signaling pathway to explain the suspected anti-colon-cancer properties of fiber-derived butyrate.

摘要

丁酸盐对组蛋白脱乙酰酶的抑制作用导致细胞周期蛋白依赖性激酶抑制剂p21/Cip1/WAF1的直接转录上调。我们讨论了一种小分子介导的信号通路，以解释纤维衍生的丁酸盐疑似的抗结肠癌特性。

相似文献

1
Fiber-derived butyrate and the prevention of colon cancer.纤维衍生的丁酸盐与结肠癌的预防
Chem Biol. 1997 Nov;4(11):783-9. doi: 10.1016/s1074-5521(97)90111-3.
2
p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells.p21（WAF1）是丁酸盐介导的人结肠癌细胞生长抑制所必需的。
Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6791-6. doi: 10.1073/pnas.95.12.6791.
3
Expression of p21(WAF1/Cip1) through Sp1 sites by histone deacetylase inhibitor apicidin requires PI 3-kinase-PKC epsilon signaling pathway.组蛋白去乙酰化酶抑制剂阿皮西丁通过Sp1位点使p21（WAF1/Cip1）表达需要PI 3-激酶-PKCε信号通路。
Oncogene. 2003 Sep 4;22(38):6023-31. doi: 10.1038/sj.onc.1206875.
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Activation of the p21WAF1/CIP1 promoter independent of p53 by the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) through the Sp1 sites.组蛋白去乙酰化酶抑制剂辛二酰苯胺异羟肟酸（SAHA）通过Sp1位点激活不依赖p53的p21WAF1/CIP1启动子。
Oncogene. 2000 Nov 23;19(50):5712-9. doi: 10.1038/sj.onc.1203963.
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Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites.组蛋白去乙酰化酶抑制剂通过Sp1位点激活WAF1/Cip1基因启动子。
Biochem Biophys Res Commun. 1997 Dec 8;241(1):142-50. doi: 10.1006/bbrc.1997.7786.
6
Sp3, but not Sp1, mediates the transcriptional activation of the p21/WAF1/Cip1 gene promoter by histone deacetylase inhibitor.组蛋白去乙酰化酶抑制剂通过Sp3而非Sp1介导p21/WAF1/Cip1基因启动子的转录激活。
Cancer Res. 1999 Sep 1;59(17):4266-70.
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Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter.组蛋白去乙酰化酶抑制剂通过其启动子中的Sp1位点激活INK4d基因。
Oncogene. 2004 Jul 8;23(31):5340-9. doi: 10.1038/sj.onc.1207689.
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Synergistic induction of apoptosis in breast cancer cells by cotreatment with butyrate and TNF-alpha, TRAIL, or anti-Fas agonist antibody involves enhancement of death receptors' signaling and requires P21(waf1).丁酸盐与肿瘤坏死因子-α（TNF-α）、肿瘤坏死因子相关凋亡诱导配体（TRAIL）或抗Fas激动剂抗体联合处理可协同诱导乳腺癌细胞凋亡，这涉及死亡受体信号传导的增强且需要P21（waf1）。
Exp Cell Res. 2004 Aug 15;298(2):560-73. doi: 10.1016/j.yexcr.2004.04.038.
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Histone deacetylase inhibitors decrease proliferation and modulate cell cycle gene expression in normal mammary epithelial cells.组蛋白去乙酰化酶抑制剂可降低正常乳腺上皮细胞的增殖并调节细胞周期基因表达。
Clin Cancer Res. 2000 Nov;6(11):4334-42.
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Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) alpha and beta messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells.组蛋白去乙酰化酶抑制剂曲古抑菌素A（TSA）和丁酸盐在SW620人结肠癌细胞中对生长停滞和DNA损伤基因45（GADD45）α和β信使核糖核酸的诱导及超诱导作用
Cancer Lett. 2002 Dec 15;188(1-2):127-40. doi: 10.1016/s0304-3835(02)00322-1.

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