Dynamic changes in gene expression during in vitro differentiation of mouse embryonic stem cells.
作者信息
Messerle M, Follo M, Nehls M, Eggert H, Boehm T
机构信息
Department of Virology, University of Heidelberg, Germany.
出版信息
Cytokines Mol Ther. 1995 Jun;1(2):139-43.
PMID:9384671
Abstract
The expression pattern of protein tyrosine kinases (PTK) and phosphatases (PTP) was determined during the first eight days of in vitro differentiation of mouse embryonic stem (ES) cells. DNA fingerprinting of catalytic domains amplified from cDNA revealed dynamic changes in expression of previously described genes. A novel PTP is expressed in undifferentiated ES cells, and is down-regulated during in vitro differentiation.
摘要
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