噬菌体Qβ核糖核酸复制酶负链合成受聚腺苷酸的优先抑制作用。
Preferential inhibition by poly(adenylic acid) of minus-strand synthesis by bacteriophage Qbeta ribonucleic acid replicase.
作者信息
Kondo M
出版信息
Biochem J. 1976 May 1;155(2):461-4. doi: 10.1042/bj1550461.
Abstract
Among the homopolymers examined, poly(A) was found to inhibit preferentially the synthesis of the minus strand by bacteriophage Qbeta RNA replicase in the presence of host factor. A specific interaction of poly(A) with the host factor is suggested to be a principal cause for the observed preferential inhibition by poly(A) of the host-factor-requiring Qbeta RNA replicase reaction.
摘要
在所检测的均聚物中，发现聚腺苷酸（poly(A)）在宿主因子存在的情况下，优先抑制噬菌体Qβ RNA复制酶合成负链。聚腺苷酸与宿主因子的特异性相互作用被认为是观察到的聚腺苷酸对需要宿主因子的Qβ RNA复制酶反应产生优先抑制作用的主要原因。
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本文引用的文献
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Subunit structure of Q-beta replicase.Q-β复制酶的亚基结构。
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Selective interference with viral RNA formation in vitro by specific inhibition with synthetic polyribonucleotides.通过合成多聚核糖核苷酸的特异性抑制在体外对病毒RNA形成的选择性干扰。
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