强直性脊柱炎患者血清中针对胶原蛋白的IgA1和IgA2亚类抗体
Serum IgA1 and IgA2 subclass antibodies against collagens in patients with ankylosing spondylitis.
作者信息
Tani Y, Sato H, Tanaka N, Mori K, Doida Y, Hukuda S
机构信息
Department of Orthopaedic Surgery, Shiga University of Medical Science, Otsu, Japan.
出版信息
Scand J Rheumatol. 1997;26(5):380-2. doi: 10.3109/03009749709065703.
We measured IgA1 and IgA2 subclass antibody levels against human type I, II, III and IV collagens in patients with ankylosing spondylitis (AS) by enzyme linked immunosorbent assay (ELISA). Significant elevations of IgA1 antibodies against type II collagen (p < 0.01) and IgA2 antibodies against type I (p < 0.001), III (p < 0.001), and IV (p < 0.01) collagens were observed in AS patients compared with those of healthy controls. These findings suggest that serum IgA antibodies against type I, III and IV collagens were mainly produced in secretory lesions in AS patients.
我们通过酶联免疫吸附测定（ELISA）测量了强直性脊柱炎（AS）患者针对人I型、II型、III型和IV型胶原蛋白的IgA1和IgA2亚类抗体水平。与健康对照组相比，AS患者中针对II型胶原蛋白的IgA1抗体（p < 0.01）以及针对I型（p < 0.001）、III型（p < 0.001）和IV型（p < 0.01）胶原蛋白的IgA2抗体显著升高。这些发现表明，AS患者中针对I型、III型和IV型胶原蛋白的血清IgA抗体主要在分泌性病变中产生。
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