David T E
Division of Cardiovascular Surgery, Toronto Hospital, University of Toronto, Ontario, Canada.
Ann Thorac Surg. 1997 Nov;64(5):1564-8. doi: 10.1016/S0003-4975(97)01026-6.
Patients with ascending aortic aneurysms often have aortic insufficiency due to dilatation of the aortic root. Although composite replacement of the aortic valve and ascending aorta has been the standard treatment, an aortic valve-sparing operation is feasible in patients with normal aortic valve leaflets.
From 1988 to 1996, 208 patients with ascending aortic aneurysms and aortic insufficiency were operated on. Aortic valve-sparing operations were performed in 101 patients: 70 men and 31 women with a mean age of 53 years (range, 14 to 82 years). Twenty-eight patients had the stigmata of Marfan's syndrome. Fifteen patients had acute and 8 had chronic type A aortic dissection. Coronary artery disease was detected in 19 patients and mitral regurgitation in 5. Two types of aortic valve-sparing operations were performed: remodeling of the aortic root with preservation of the aortic valve in 73 patients and reimplantation of the aortic valve in a tubular Dacron graft in 28. Patients were followed up from 3 to 108 months (mean, 31 months). Doppler echocardiographic studies were performed annually.
There were two operative deaths. One patient had to have aortic valve replacement because of persistent aortic insufficiency. There were five late deaths; the actuarial survival rate at 6 years was 87% +/- 5%. One patient required aortic valve replacement 2 years after the initial operation; the freedom from aortic valve replacement at 6 years was 97% +/- 2%. There have been no thromboembolic or infective complications. Only 3 patients have moderate aortic insufficiency; the remaining patients have mild or no aortic insufficiency.
The midterm results of aortic valve-sparing operations have been excellent and justify their continued use in patients with aortic root aneurysms and normal or near-normal aortic valve leaflets.
升主动脉瘤患者常因主动脉根部扩张而出现主动脉瓣关闭不全。尽管主动脉瓣和升主动脉的复合置换一直是标准治疗方法,但对于主动脉瓣叶正常的患者,保留主动脉瓣的手术是可行的。
1988年至1996年,对208例升主动脉瘤合并主动脉瓣关闭不全患者进行了手术。101例患者接受了保留主动脉瓣的手术:70例男性和31例女性,平均年龄53岁(范围14至82岁)。28例患者有马凡综合征的体征。15例患者为急性A型主动脉夹层,8例为慢性A型主动脉夹层。19例患者检测出冠状动脉疾病,5例患者有二尖瓣反流。进行了两种保留主动脉瓣的手术:73例患者行主动脉根部重塑并保留主动脉瓣,28例患者将主动脉瓣重新植入涤纶人工血管。对患者进行了3至108个月(平均31个月)的随访。每年进行多普勒超声心动图检查。
有2例手术死亡。1例患者因持续性主动脉瓣关闭不全而不得不进行主动脉瓣置换。有5例晚期死亡;6年的精算生存率为87%±5%。1例患者在初次手术后2年需要进行主动脉瓣置换;6年时无需主动脉瓣置换的比例为97%±2%。未发生血栓栓塞或感染并发症。只有3例患者有中度主动脉瓣关闭不全;其余患者有轻度或无主动脉瓣关闭不全。
保留主动脉瓣手术的中期结果非常好,证明其可继续用于主动脉根部瘤且主动脉瓣叶正常或接近正常的患者。