David T E, Armstrong S, Ivanov J, Feindel C M, Omran A, Webb G
Divisions of Cardiovascular Surgery and Cardiology of Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.
J Thorac Cardiovasc Surg. 2001 Jul;122(1):39-46. doi: 10.1067/mtc.2001.112935.
To review the late results of valve-sparing operations in patients with aortic root aneurysm and in those with ascending aortic aneurysm and aortic insufficiency.
From May 1988 to June 2000, 120 patients with aortic root aneurysm and 68 with ascending aortic aneurysm and aortic insufficiency underwent aortic valve-sparing operations. Patients with aortic root aneurysm were younger, were predominantly male, and had less severe aortic insufficiency than patients with ascending aortic aneurysm, who were older and often had aneurysm of the transverse arch. Forty-eight patients with aortic root aneurysm had the Marfan syndrome. The prevalence of aortic dissection was similar in both groups. Reconstruction of the aortic root was performed by reimplanation of the aortic valve in 64 patients and by remodeling of the aortic root in 56. Patients with ascending aortic aneurysm and aortic insufficiency were treated by replacement of the ascending aorta with reduction in the diameter of the sinotubular junction. Approximately two thirds of the latter patients also required replacement of the transverse aortic arch. The mean follow-up was 35 +/- 31 months for patients with aortic root aneurysm and 26 +/- 23 months for those with ascending aortic aneurysm.
There were 2 operative and 5 late deaths in patients with aortic root aneurysm and 1 operative and 9 late deaths in patients with ascending aortic aneurysm. The 5-year survival for patients with aortic root aneurysm was 88% +/- 4% and for patients with ascending aortic aneurysm, 68% +/- 12% (P =.01). Severe aortic insufficiency developed in 2 patients, and they required aortic valve reoperation. The 5-year freedom from aortic valve reoperation was 99% +/- 1% for patients with aortic root aneurysm and 97% +/- 4% for those with ascending aortic aneurysm. Seven patients had moderate aortic insufficiency at the latest echocardiographic study. The 5-year freedom from severe or moderate aortic insufficiency was 90% +/- 4% in patients who had aortic root aneurysm and 98% +/- 2% in those who had ascending aortic aneurysm.
Aortic valve-sparing operations have provided excellent clinical outcomes and few valve-related complications. The function of the reconstructed aortic root remains unchanged in most patients during the first 5 years of follow-up.
回顾主动脉根部瘤患者以及升主动脉瘤合并主动脉瓣关闭不全患者保留瓣膜手术的远期结果。
1988年5月至2000年6月,120例主动脉根部瘤患者和68例升主动脉瘤合并主动脉瓣关闭不全患者接受了保留主动脉瓣手术。主动脉根部瘤患者较年轻,以男性为主,主动脉瓣关闭不全程度较升主动脉瘤患者轻,后者年龄较大,且常合并横弓动脉瘤。48例主动脉根部瘤患者患有马方综合征。两组主动脉夹层的发生率相似。64例患者通过主动脉瓣再植入进行主动脉根部重建,56例通过主动脉根部重塑进行重建。升主动脉瘤合并主动脉瓣关闭不全患者采用升主动脉置换并缩小窦管交界直径进行治疗。约三分之二的后一组患者还需要置换主动脉横弓。主动脉根部瘤患者的平均随访时间为35±31个月,升主动脉瘤患者为26±23个月。
主动脉根部瘤患者有2例手术死亡和5例晚期死亡,升主动脉瘤患者有1例手术死亡和9例晚期死亡。主动脉根部瘤患者的5年生存率为88%±4%,升主动脉瘤患者为68%±12%(P = 0.01)。2例患者出现严重主动脉瓣关闭不全,需要再次进行主动脉瓣手术。主动脉根部瘤患者5年无主动脉瓣再次手术率为99%±1%,升主动脉瘤患者为97%±4%。在最近一次超声心动图检查中,7例患者有中度主动脉瓣关闭不全。主动脉根部瘤患者5年无严重或中度主动脉瓣关闭不全率为90%±4%,升主动脉瘤患者为98%±2%。
保留主动脉瓣手术取得了良好的临床效果,瓣膜相关并发症较少。在随访的前5年中,大多数患者重建后的主动脉根部功能保持不变。