Lee H C
Department of Physiology, University of Minnesota, Minneapolis 55455, USA.
Cell Biochem Biophys. 1998;28(1):1-17. doi: 10.1007/BF02738306.
Ca2+ mobilization as a signaling mechanism has been placed on center stage with the discovery of the first Ca2+ messenger, inositol trisphosphate (IP3). This article focuses on two new Ca2+ release activators, which mobilize internal Ca2+ stores via mechanisms totally independent of IP3. They are cyclic ADP-ribose (cADPR) and nicotinic acid dinucleotide phosphate (NAADP), metabolites derived respectively from NAD and NADP. Major advances in the past decade in the understanding of these two novel signaling mechanisms are chronologically summarized.
随着首个钙离子信使——肌醇三磷酸（IP3）的发现，钙离子动员作为一种信号传导机制已成为焦点。本文着重介绍两种新的钙离子释放激活剂，它们通过完全独立于IP3的机制动员细胞内钙离子储备。它们分别是环二磷酸腺苷核糖（cADPR）和烟酰胺腺嘌呤二核苷酸磷酸（NAADP），分别由NAD和NADP衍生而来的代谢产物。按时间顺序总结了过去十年在理解这两种新型信号传导机制方面取得的主要进展。
