Martinez E A, Wooldridge A A, Hartsfield S M
Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station 77843-4474, USA.
Vet Surg. 1997 Nov-Dec;26(6):510-4. doi: 10.1111/j.1532-950x.1997.tb00527.x.
The purpose of this study was to determine the effect of ketorolac tromethamine or placebo on the neuromuscular blockade induced by an infusion of atracurium in isoflurane-anesthetized dogs.
Randomized, controlled trial.
Six healthy, adult mixed-breed dogs (five female, one male) weighing 24.8 +/- 2.8 kg.
Dogs were studied on two occasions with a minimum of 7 days between studies. Dogs were induced with 5% isoflurane in oxygen and maintained with 1.6 x minimum alveolar concentration (MAC) end-tidal isoflurane. Neuromuscular blockade was assessed using the train-of-four response. Once 50% depression of the first twitch (T1) was achieved, the atracurium infusion rate was held constant for 30 minutes. Then ketorolac, 0.5 mg/kg, or the same volume of placebo (0.9% sodium chloride solution) was administered intravenously and the atracurium infusion maintained for an additional 60 minutes. Before and at 2, 5, 10, 15, 30, and 60 minutes after ketorolac or placebo, the percent depression of T1 and the fourth twitch to the first twitch (T4/T1) ratio were recorded. The atracurium infusion was discontinued and the time for T1 to recover from 50% to 75% of its original value was recorded. At 75% T1, edrophonium, 0.5 mg/kg intravenously, was administered to antagonize the residual blockade.
There was no significant difference in T1%, T4/T1 ratio, or recovery time after ketorolac administration compared with placebo.
Ketorolac, 0.5 mg/kg intravenously, has no significant effect on either atracurium-induced neuromuscular blockade or recovery time for T1 in isoflurane-anesthetized dogs.
The concurrent use of atracurium should not be a contraindication for the administration of ketorolac for intraoperative or postoperative analgesia.
本研究旨在确定酮咯酸氨丁三醇或安慰剂对异氟烷麻醉犬输注阿曲库铵所致神经肌肉阻滞的影响。
随机对照试验。
6只健康成年杂种犬（5只雌性，1只雄性），体重24.8±2.8千克。
犬只分两次进行研究，两次研究间隔至少7天。犬只以5%异氟烷吸入诱导麻醉，维持呼气末异氟烷浓度为1.6倍最低肺泡有效浓度（MAC）。采用四个成串刺激反应评估神经肌肉阻滞。当第一个肌颤搐（T1）抑制达50%时，阿曲库铵输注速率维持恒定30分钟。然后静脉注射酮咯酸0.5毫克/千克或等体积安慰剂（0.9%氯化钠溶液），阿曲库铵继续输注60分钟。在注射酮咯酸或安慰剂前及注射后2、5、10、15、30和60分钟，记录T1抑制百分比及第四个肌颤搐与第一个肌颤搐的比值（T4/T1）。停止阿曲库铵输注，记录T1从其初始值的50%恢复至75%所需时间。当T1恢复至75%时，静脉注射依酚氯铵0.5毫克/千克以拮抗残余阻滞。
与安慰剂相比，注射酮咯酸后T1百分比、T4/T1比值或恢复时间无显著差异。
静脉注射0.5毫克/千克酮咯酸对异氟烷麻醉犬阿曲库铵诱导的神经肌肉阻滞或T1恢复时间无显著影响。
同时使用阿曲库铵不应成为术中或术后镇痛使用酮咯酸的禁忌证。
