[肝硬化门静脉高压症患者肝组织中α1肾上腺素能受体的放射自显影研究]
[An autoradiographic study of alpha 1-adrenoceptors in hepatic tissues in cirrhotic patients with portal hypertension].
作者信息
Feng H, Leng X, Xu Q
机构信息
Department of Surgery, People's Hospital, Beijing Medical University.
出版信息
Zhonghua Wai Ke Za Zhi. 1996 Mar;34(3):141-3.
We studied hepatic alpha 1-adrenoceptors of 8 hepatitis virus B-related cirrhotic patients with portal hypertension and 8 control surgical patients without liver disease by light radioautography. The density of alpha 1-adrenoceptors in various hepatic structures ("healthy" control vs. patients, per 10,000 microns 2) was as follows: on hypatocytes 1255.07 +/- 151.44/583.37 +/- 47.64 (P < 0.01); on intrahepatic artery walls 705.06 +/- 188.68/183.54 +/- 46.77 (P < 0.01); on intrahepatic portal walls 409.98 +/- 88.73/154.02 +/- 20.65 (P < 0.01); on hepatic venule walls 339.29 +/- 94.85/.... The decrease of density of alpha 1-adrenoceptors in cirrhotic liver tissues may be a result of the destruction of nomal hepatic structure by hepatitis virus B and the down-regulation of alpha 1-adrenoceptors.
我们通过放射自显影法对8例乙型肝炎病毒相关性肝硬化门静脉高压患者及8例无肝脏疾病的对照手术患者的肝脏α1-肾上腺素能受体进行了研究。不同肝脏结构中α1-肾上腺素能受体的密度（“健康”对照与患者相比，每10,000平方微米）如下：肝细胞上为1255.07±151.44/583.37±47.64（P<0.01）；肝内动脉壁上为705.06±188.68/183.54±46.77（P<0.01）；肝内门静脉壁上为409.98±88.73/154.02±20.65（P<0.01）；肝小静脉壁上为339.29±94.85/.... 肝硬化肝组织中α1-肾上腺素能受体密度的降低可能是乙型肝炎病毒破坏正常肝脏结构以及α1-肾上腺素能受体下调的结果。
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