Zhu J, Du R, Leng X
Department of Surgery, People's Hospital, Beijing Medical University.
Zhonghua Wai Ke Za Zhi. 1996 Mar;34(3):144-6.
High Pressure Liquid chromatography was used to measure serum adrenaline (E) and noradrenaline (NE) concentrations in 38 portal hypertensive patients, 28 idiopathic hypertensive patients, and 34 controls, respectively. It was found that peripheral E in portal hypertensive patients and controls was 57.5 +/- 37.4 pg/ml and 23.5 +/- 11.2 pg/ml respectively (P < 0.01), and peripheral NE was 451.1 +/- 381.2 pg/ml and 183.0 +/- 83.3 pg/ml (P < 0.01). Compared with controls, peripheral E and NE in idiopathic hypertensive patients were also significantly increased (54.9 +/- 39.9 pg/ml vs. 23.6 +/- 11.2 pg/ml, P < 0.01, and 524.3 +/- 219.9 pg/ml vs. 183.0 +/- 83.3 pg/ml, P < 0.01). E and NE in superior vena cava (SVC), portal vein, and peripheral artery in portal hypertensive patients were also increased, but only the elevation of E in SVC was significant (207.2 +/- 55.4 pg/ml vs. 83.7 +/- 46.7 pg/ml, P < 0.05). Our results reveal significant metabolic disorders of E and NE in portal hypertensive patients, which may play an important role in the pathogenesis of portal hypertension.
采用高效液相色谱法分别测定了38例门静脉高压患者、28例特发性高血压患者和34例对照者血清肾上腺素（E）和去甲肾上腺素（NE）浓度。结果发现，门静脉高压患者和对照者外周血E分别为57.5±37.4 pg/ml和23.5±11.2 pg/ml（P<0.01），外周血NE分别为451.1±381.2 pg/ml和183.0±83.3 pg/ml（P<0.01）。与对照者相比，特发性高血压患者外周血E和NE也显著升高（54.9±39.9 pg/ml对23.6±11.2 pg/ml，P<0.01；524.3±219.9 pg/ml对183.0±83.3 pg/ml，P<0.01）。门静脉高压患者上腔静脉（SVC）、门静脉和外周动脉中的E和NE也升高，但仅SVC中E的升高具有显著性（207.2±55.4 pg/ml对83.7±46.7 pg/ml，P<0.05）。我们的研究结果揭示了门静脉高压患者E和NE存在明显的代谢紊乱，这可能在门静脉高压的发病机制中起重要作用。
