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诺卡氏菌ATCC 31190将乙苯微生物转化为1-苯乙醇和苯乙酮。

Microbial conversion of ethylbenzene to 1-phenethanol and acetophenone by Nocardia tartaricans ATCC 31190.

作者信息

Cox D P, Goldsmith C D

出版信息

Appl Environ Microbiol. 1979 Sep;38(3):514-20. doi: 10.1128/aem.38.3.514-520.1979.

DOI:10.1128/aem.38.3.514-520.1979
PMID:93878
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC243525/
Abstract

A culture of Nocardia tartaricans ATCC 31190 was capable of catalyzing the conversion of ethylbenzene to 1-phenethanol and acetophenone while growing in a shake flask culture with hexadecane as the source of carbon and energy. This subterminal oxidative reaction with ethylbenzene appears not to have been previously reported for Nocardia species. When N. tartaricans was grown on glucose as its source of carbon and energy and ethylbenzene was added, no subsequent production of 1-phenethanol or acetophenone was observed. The mechanisms of 1-phenethanol and acetophenone production from ethylbenzene are thought to involve a subterminal oxidation of the alpha-carbon of the alkyl group to 1-phenethanol followed by biological oxidation of the latter to acetophenone.

摘要

在以十六烷作为碳源和能源的摇瓶培养中生长时,龋齿诺卡氏菌ATCC 31190的培养物能够催化乙苯转化为1-苯乙醇和苯乙酮。这种与乙苯的亚末端氧化反应似乎此前尚未见诺卡氏菌属的相关报道。当龋齿诺卡氏菌以葡萄糖作为碳源和能源进行培养并添加乙苯时,未观察到随后有1-苯乙醇或苯乙酮的产生。由乙苯生成1-苯乙醇和苯乙酮的机制被认为涉及烷基α-碳的亚末端氧化生成1-苯乙醇,随后后者再进行生物氧化生成苯乙酮。

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本文引用的文献

1
Oxidation of alkyl-substituted cyclic hydrocarbons by a Nocardia during growth on n-alkanes.诺卡氏菌在正构烷烃上生长时对烷基取代环烃的氧化作用。
Appl Microbiol. 1961 Sep;9(5):383-8. doi: 10.1128/am.9.5.383-388.1961.
2
Effect of chloramphenicol in maintaining the viability of Escherichia coli.氯霉素在维持大肠杆菌活力方面的作用。
Nature. 1956 Dec 29;178(4548):1467. doi: 10.1038/1781467a0.
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Studies in detoxication. 56. The metabolism of alkylbenzenes: stereochemical aspects of the biological hydroxylation of ethylbenzene to methylphenylcarbinol.解毒研究。56. 烷基苯的代谢:乙苯生物羟基化生成甲基苯基甲醇的立体化学方面。
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Oxidative metabolism of naphthalene by soil pseudomonads. The ring-fission mechanism.土壤假单胞菌对萘的氧化代谢。环裂解机制。
Biochem J. 1964 May;91(2):251-61. doi: 10.1042/bj0910251.
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Hydrocarbon cooxidation in microbial systems.微生物系统中的烃类共氧化
Lipids. 1971 Jul;6(7):453-7. doi: 10.1007/BF02531228.
6
Microbial degradation of hydrocarbons. Catabolism of 1-phenylalkanes by Nocardia salmonicolor.碳氢化合物的微生物降解。鲑色诺卡氏菌对1-苯基烷烃的分解代谢。
Biochem J. 1974 Apr;140(1):31-45. doi: 10.1042/bj1400031.
7
The metabolism of 1-phenylethanol and acetophenone by Nocardia T5 and an Arthrobacter species.诺卡氏菌T5和一种节杆菌对1-苯乙醇和苯乙酮的代谢
Eur J Biochem. 1978 May;86(1):175-86. doi: 10.1111/j.1432-1033.1978.tb12297.x.