三联抗菌方案治疗中性粒细胞减少癌症患者的感染
Triple combination antimicrobial regimen in the treatment of infections of neutropenic cancer patients.
作者信息
Casali A, Santini S, Della Giulia M, Di Lauro L, Vici P, Gionfra T, Sega F M
机构信息
Regina Elena Institute for Cancer Research, Rome, Italy.
出版信息
J Exp Clin Cancer Res. 1997 Sep;16(3):321-4.
Twenty-six cancer patients (pts) with chemotherapy-related neutropenic fever were treated with vancomycin 30 mg/m2/day i.v. every 12 hrs, imipenem 1500 mg/day i.v. every 8 hrs, and pefloxacin 800 mg/day i.v. every 12 hrs. Twelve fevers of unknown origin (FUO), 10 gram-positive, 3 gram-negative and 1 mycoplasma were also treated. Globally, cure was observed in 22 pts (84%) and failure in 4 pts (16%); in gram-positive infections alone, cure was observed in 10 pts (80%) and failure in 4 pts (20%). Defervescence was obtained within 3 days in 77% pts. No relevant side effects were observed.
26例化疗相关性中性粒细胞减少性发热的癌症患者接受了如下治疗：静脉注射万古霉素，剂量为30mg/m²/天，每12小时一次；亚胺培南，剂量为1500mg/天，每8小时一次；培氟沙星，剂量为800mg/天，每12小时一次。同时还治疗了12例不明原因发热（FUO）患者、10例革兰氏阳性菌感染患者、3例革兰氏阴性菌感染患者和1例支原体感染患者。总体而言，22例患者（84%）治愈，4例患者（16%）治疗失败；仅革兰氏阳性菌感染患者中，10例患者（80%）治愈，4例患者（20%）治疗失败。77%的患者在3天内退热。未观察到相关副作用。
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