Szczepańska-Sadowska E, Sobocińska J, Kozłowski S
Arch Int Physiol Biochim. 1979 Oct;87(4):673-86. doi: 10.3109/13813457909070528.
Body temperature, water intake, urine output, sodium and potassium excretion, osmolal and free water clearance, plasma osmolality, sodium and potassium concentrations and osmotic thirst were examined in conscious dogs during pyrogen fever and compared to those found under control conditions. Arterial blood pressure and central venous pressure were also measured in some experiments. Administration of pyrogen produced transient but significant decreases in urine output and striking increases in the spontaneous water intake in some of the experiments in the phase of increasing fever. Arterial blood pressure decreased, whetreas central venous pressure increased at this stage of fever. No significant changes in renal excretion of solutes and free water as well as sodium and potassium were found. Plasma osmolality and sodium concentration increased and potassium concentration decreased unsignificantly both in control and pyrogen experiments. The main finding was that the thirst threshold to osmotic stimuli increased markedly during the phase of stabilized fever may be caused by significant increase in internal body temperature.
在清醒犬发热期间，检测了其体温、水摄入量、尿量、钠和钾排泄、渗透清除率和自由水清除率、血浆渗透压、钠和钾浓度以及渗透性口渴，并与对照条件下的结果进行比较。在一些实验中还测量了动脉血压和中心静脉压。在发热上升期的一些实验中，注射热原导致尿量短暂但显著减少，同时自发性水摄入量显著增加。在此发热阶段，动脉血压下降，而中心静脉压升高。未发现肾溶质和自由水以及钠和钾排泄有显著变化。在对照和热原实验中，血浆渗透压和钠浓度均升高，钾浓度无显著降低。主要发现是，在稳定发热期，对渗透刺激的口渴阈值显著升高，这可能是由于体内温度显著升高所致。
