丝氨酸/苏氨酸激酶Akt在胰岛素刺激的葡萄糖摄取中的作用。 - Suppr

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超能文献

A role for the serine/threonine kinase, Akt, in insulin-stimulated glucose uptake.

作者信息

Summers S A, Birnbaum M J

机构信息

Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia 19104-6148, USA.

出版信息

Biochem Soc Trans. 1997 Aug;25(3):981-8. doi: 10.1042/bst0250981.

DOI:10.1042/bst0250981

PMID:9388586

Abstract

摘要

相似文献

A role for the serine/threonine kinase, Akt, in insulin-stimulated glucose uptake.丝氨酸/苏氨酸激酶Akt在胰岛素刺激的葡萄糖摄取中的作用。

Biochem Soc Trans. 1997 Aug;25(3):981-8. doi: 10.1042/bst0250981.

Akt mediates insulin induction of glucose uptake and up-regulation of GLUT4 gene expression in brown adipocytes.Akt介导胰岛素诱导棕色脂肪细胞摄取葡萄糖以及上调GLUT4基因的表达。

FEBS Lett. 2001 Apr 13;494(3):225-31. doi: 10.1016/s0014-5793(01)02353-5.

Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport.胰岛素刺激蛋白质合成而非葡萄糖转运过程中丝氨酸 - 苏氨酸激酶Akt（蛋白激酶B）激活的需求。

Mol Cell Biol. 1998 Jul;18(7):3708-17. doi: 10.1128/MCB.18.7.3708.

Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats.糖尿病GK大鼠中胰岛素信号传导至葡萄糖转运的肌纤维类型特异性缺陷。

Diabetes. 1999 Mar;48(3):664-70. doi: 10.2337/diabetes.48.3.664.

Effects of adenoviral gene transfer of wild-type, constitutively active, and kinase-defective protein kinase C-lambda on insulin-stimulated glucose transport in L6 myotubes.野生型、组成型激活型和激酶缺陷型蛋白激酶C-λ的腺病毒基因转移对L6肌管中胰岛素刺激的葡萄糖转运的影响。

Endocrinology. 2000 Nov;141(11):4120-7. doi: 10.1210/endo.141.11.7766.

High leptin levels acutely inhibit insulin-stimulated glucose uptake without affecting glucose transporter 4 translocation in l6 rat skeletal muscle cells.高瘦素水平可急性抑制胰岛素刺激的葡萄糖摄取，而不影响L6大鼠骨骼肌细胞中葡萄糖转运蛋白4的易位。

Endocrinology. 2001 Nov;142(11):4806-12. doi: 10.1210/endo.142.11.8496.

Role of protein kinase B in insulin-regulated glucose uptake.蛋白激酶B在胰岛素调节的葡萄糖摄取中的作用。

Biochem Soc Trans. 2005 Apr;33(Pt 2):346-9. doi: 10.1042/BST0330346.

Overexpression of wild-type Akt1 promoted insulin-stimulated p70S6 kinase (p70S6K) activity and affected GSK3 beta regulation, but did not promote insulin-stimulated GLUT4 translocation or glucose transport in L6 myotubes.野生型Akt1的过表达促进了胰岛素刺激的p70S6激酶（p70S6K）活性，并影响了糖原合成酶激酶3β（GSK3β）的调节，但并未促进胰岛素刺激的葡萄糖转运蛋白4（GLUT4）在L6肌管中的转位或葡萄糖转运。

J Med Invest. 2000 Feb;47(1-2):47-55.

Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes.雷帕霉素哺乳动物靶点通路的激活会急性抑制3T3-L1细胞和人脂肪细胞中胰岛素向Akt的信号传导以及葡萄糖转运。

Endocrinology. 2005 Mar;146(3):1328-37. doi: 10.1210/en.2004-0777. Epub 2004 Dec 2.

1-[N, O-bis-(5-isoquinolinesulphonyl)-N-methyl-L-tyrosyl]-4- phenylpiperazine (KN-62), an inhibitor of calcium-dependent camodulin protein kinase II, inhibits both insulin- and hypoxia-stimulated glucose transport in skeletal muscle.1-[N,O-双-(5-异喹啉磺酰基)-N-甲基-L-酪氨酰基]-4-苯基哌嗪（KN-62），一种钙依赖性钙调蛋白激酶II的抑制剂，可抑制骨骼肌中胰岛素和缺氧刺激的葡萄糖转运。

Biochem J. 1999 May 1;339 ( Pt 3)(Pt 3):533-40.

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