Mao C, Lu Y, Lai Q, Xia Y, Yang C
PUMC Hospital, CAMS, Beijing.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1996 Aug;18(4):257-62.
One hundred and eleven cases of oral squamous cell carcinoma (OSCC) were examined for overexpression of p53 protein by using immunohistochemical technique. Association of p53 protein overexpression with clinical and pathological parameters as well as prognosis of patients were also analyzed, p53 protein overexpression was commonly observed (69.4%) in the OSCC patients and might be used as a marker of carcinogenesis of OSCC. The level of p53 protein overexpression was correlated with the decreased three and/or five-year survival rate of OSCC. The presence of p53 was not correlated with patient's sex and age, site and size of tumor, degree of differentiation, node status or clinical stage of OSCC. Single factor COX proportional hazards regression model analysis indicated that there was no significant relationship between p53 overexpression and prognosis of OSCC. Multivariable COX model analysis failed to establish effective life function or risk rate function. This showed that all the parameters analyzed in this study as well as p53 overexpression were not significant or effective risk factors to predict prognosis of OSCC patients.
采用免疫组织化学技术检测了111例口腔鳞状细胞癌（OSCC）患者的p53蛋白过表达情况。同时分析了p53蛋白过表达与临床病理参数以及患者预后的关系，p53蛋白过表达在OSCC患者中普遍存在（69.4%），可能作为OSCC致癌作用的一个标志物。p53蛋白过表达水平与OSCC患者3年和/或5年生存率降低相关。p53的存在与患者的性别、年龄、肿瘤部位和大小、分化程度、淋巴结状态或OSCC的临床分期无关。单因素COX比例风险回归模型分析表明，p53过表达与OSCC预后无显著关系。多变量COX模型分析未能建立有效的生存函数或风险率函数。这表明本研究中分析的所有参数以及p53过表达均不是预测OSCC患者预后的显著或有效风险因素。
