印戒细胞淋巴瘤的针吸细胞学检查。病例报告。

Aspiration cytology of signet-ring cell lymphoma. A case report.

作者信息

Cangiarella J, Weg N, Symmans W F, Waisman J

机构信息

Department of Pathology, New York University School of Medicine, New York 10016, USA.

出版信息

Acta Cytol. 1997 Nov-Dec;41(6):1828-32. doi: 10.1159/000333196.

DOI:10.1159/000333196

PMID:9390152

Abstract

BACKGROUND

Signet-ring cell lymphoma is a rare subtype of non-Hodgkin's lymphoma, composed of vacuolated cells with a signet-ring cell appearance. We found only two cases that had been reported as diagnosed by fine needle aspiration biopsy.

CASE

A 61-year-old female had signet-ring cell lymphoma diagnosed by computed tomography-guided aspiration biopsy. Smears of aspirates from her retroperitoneal mass contained a population of small to medium-sized, angular lymphoid cells; lymphoglandular bodies; and an abundance of signet-ring cells. The signet-ring cells were negative for cytokeratin and positive for leukocyte common antigen and CD20, a B-cell marker. Monoclonality for lambda light chain determinant was noted, and a diagnosis of signet-ring cell lymphoma of the B-cell type was made. A core biopsy specimen confirmed the diagnosis.

CONCLUSION

Signet-ring cell lymphoma should always be considered in the differential diagnosis of tumors composed of signet-ring cells.

摘要

背景

印戒细胞淋巴瘤是非霍奇金淋巴瘤的一种罕见亚型，由具有印戒样细胞外观的空泡状细胞组成。我们仅发现两例经细针穿刺活检确诊的报道病例。

病例

一名61岁女性经计算机断层扫描引导下穿刺活检诊断为印戒细胞淋巴瘤。她腹膜后肿块抽吸物涂片包含一群中小等大小、有角的淋巴细胞；淋巴腺小体；以及大量印戒细胞。印戒细胞细胞角蛋白阴性，白细胞共同抗原及B细胞标志物CD20阳性。观察到λ轻链决定簇的单克隆性，诊断为B细胞型印戒细胞淋巴瘤。一份芯针活检标本证实了诊断。