Trinder J, Van Beveren J A, Smith P, Kleiman J, Kay A
School of Behavioural Science, University of Melbourne, Parkville, Victoria 3052, Australia.
J Appl Physiol (1985). 1997 Dec;83(6):2005-11. doi: 10.1152/jappl.1997.83.6.2005.
In studies of elderly individuals, ventilation and EEG-defined arousal have been shown to vary periodically and synchronously. Such results have been interpreted as indicating the primacy of sleep/wake state in causing ventilatory instability during sleep onset. However, because the elderly individuals studied were periodic breathers, the results do not unequivocally support this conclusion. In this study the relationship between ventilation and EEG-defined arousal was assessed in a group of 21 young, healthy men in whom ventilatory instability during sleep onset was not periodic. Ventilation and EEG (O1-A2) recordings were collected, and the longest uncontaminated periods from early and late in sleep onset were selected for subsequent analysis. The 84 time series (21 subjects, 2 variables, and 2 occasions in sleep onset) were subjected to spectral analysis to identify periodicity, and the relationship between the two variables was determined by cross-correlational methods. The results indicated that the time series were nonperiodic, yet significant correlations were observed between the two variables. The data support the view that during sleep onset ventilatory instability is driven primarily by variations in sleep/wake arousal level.
在针对老年人的研究中，通气与脑电图定义的觉醒已被证明会周期性且同步地变化。此类结果被解释为表明在睡眠开始期间导致通气不稳定方面，睡眠/觉醒状态具有首要地位。然而，由于所研究的老年人是周期性呼吸者，这些结果并不能明确支持这一结论。在本研究中，对一组21名年轻健康男性进行了通气与脑电图定义的觉醒之间关系的评估，这些男性在睡眠开始期间的通气不稳定并非周期性的。收集了通气和脑电图（O1 - A2）记录，并从睡眠开始的早期和晚期选取最长的未受污染时间段用于后续分析。对这84个时间序列（21名受试者，2个变量，以及睡眠开始时的2个时段）进行频谱分析以确定周期性，并通过互相关方法确定两个变量之间的关系。结果表明，时间序列是非周期性的，但在两个变量之间观察到了显著的相关性。这些数据支持这样一种观点，即在睡眠开始期间，通气不稳定主要由睡眠/觉醒觉醒水平的变化驱动。
