Hashim S R, Fontaine A, He S, Levine R A, Yoganathan A P
Cardiovascular Fluid Mechanics Laboratory, School of Chemical Engineering, Georgia Institute of Technology, Atlanta 30332, USA.
J Biomech. 1997 Oct;30(10):1071-5. doi: 10.1016/s0021-9290(97)00066-3.
Recent clinical studies indicate that functional mitral regurgitation, which is a common complication in patients who suffer from ischemic heart disease, is related to an increase in the tethering forces acting on the mitral valve leaflets. Alterations in the valvular assembly, displacement of the papillary muscles or dilatation of the mitral valve annulus can disrupt the normal force balance on the mitral leaflets and result in an abnormal coaptation geometry with incomplete mitral leaflet closure. The force balance imposed on the mitral leaflets is created by the coapting forces generated by the transmitral pressure difference and the tethering forces at the leaflet attachments. A unique force vector cell capable of accurately measuring the three-component force vector applied by the papillary muscle on the left-ventricular wall was designed and manufactured to permit quantification of the alteration in the force balance acting on the mitral leaflets, and to allow for the study of the influence of papillary muscle displacement on mitral regurgitation.
最近的临床研究表明，功能性二尖瓣反流是缺血性心脏病患者的常见并发症，它与作用于二尖瓣小叶的系留力增加有关。瓣膜组件的改变、乳头肌移位或二尖瓣环扩张会破坏二尖瓣小叶上的正常力平衡，并导致二尖瓣小叶闭合不完全的异常对合几何形状。作用于二尖瓣小叶的力平衡是由跨二尖瓣压差产生的对合力和小叶附着处的系留力共同形成的。设计并制造了一种独特的力矢量单元，能够精确测量乳头肌施加在左心室壁上的三分量力矢量，以便对作用于二尖瓣小叶的力平衡变化进行量化，并研究乳头肌移位对二尖瓣反流的影响。
