一只狗的葡萄糖-6-磷酸脱氢酶缺乏症
Glucose-6-phosphate dehydrogenase deficiency in a dog.
作者信息
Smith J E, Ryer K, Wallace L
出版信息
Enzyme. 1976;21(4):379-82. doi: 10.1159/000458882.
PMID:939229
Abstract
After screening 3,300 dogs, one animal with a mild deficiency of erythrocyte G6PD was detected. Although it had several clinical problems for 2 months, no abnormality could be directly attributable to the reduced enzymatic activity. Biochemically the mutant was electrophoretically slower but within the normal range for Km-G6P, Km-NADP, use of 2-dG6P and deamino NADP, pH optimum, and heat stability.
摘要
在对3300只狗进行筛查后，检测到一只红细胞葡萄糖-6-磷酸脱氢酶（G6PD）轻度缺乏的动物。尽管它在两个月内出现了一些临床问题，但没有任何异常可直接归因于酶活性降低。从生化角度来看，该突变体在电泳时迁移较慢，但在Km-G6P、Km-NADP、对2-脱氧葡萄糖-6-磷酸（2-dG6P）和脱氨基NADP的利用、最适pH值以及热稳定性等方面均在正常范围内。
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