肠抑胃素在大鼠杏仁核和室旁核中发挥作用以抑制进食。

Enterostatin actions in the amygdala and PVN to suppress feeding in the rat.

作者信息

Lin L, York D A

机构信息

Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808-4124, USA.

出版信息

Peptides. 1997;18(9):1341-7. doi: 10.1016/s0196-9781(97)00191-5.

DOI:10.1016/s0196-9781(97)00191-5

PMID:9392835

Abstract

The pentapeptide enterostatin (ENT) inhibits feeding after injection into the cerebral ventricles. To localize the central sites of action of ENT, the peptide (0.01 to 3.3 nM) was microinjected into several brain regions and the intake of a high fat diet was measured. The results show that ENT injection in the paraventricular nucleus (PVN) or the amygdala (AMYG) produced a bi-phasic dose related feeding response, low doses of ENT inhibited feeding while higher dose had no effect. The effective dose to inhibit feeding in the AMYG was 10 fold lower than that in the PVN. No changes in food intake were observed after ENT injection into the ventromedial hypothalamus and nucleus tractus solitarius. The data provide further support that there are targets in the CNS for ENT and suggest that central ENT function is site specific.

摘要

五肽肠抑素（ENT）注入脑室后可抑制进食。为确定ENT的中枢作用位点，将该肽（0.01至3.3 nM）微量注射到几个脑区，并测量高脂饮食的摄入量。结果显示，向室旁核（PVN）或杏仁核（AMYG）注射ENT产生双相剂量相关的进食反应，低剂量的ENT抑制进食，而高剂量则无作用。在杏仁核中抑制进食的有效剂量比在室旁核中低10倍。向腹内侧下丘脑和孤束核注射ENT后未观察到食物摄入量的变化。这些数据进一步支持了中枢神经系统中存在ENT的作用靶点，并表明中枢ENT功能具有位点特异性。