Drago F, Stanciu M, Salehi S, Scapagnini U
Institute of Pharmacology, University of Catania Medical School, Italy.
Peptides. 1997;18(9):1389-92. doi: 10.1016/s0196-9781(97)00203-9.
The role of central vasopressin V1 receptors in grooming behavior induced by vasopressin and oxytocin was studied in male rats of the Wistar strain. The intracerebroventricular (ICV) injection of vasopressin (3 micrograms/5 microliters) induced hypothermia and enhanced novelty-induced grooming behavior. Enhanced grooming but not hypothermia was also induced by ICV injection of oxytocin (3 micrograms/5 microliters). The central administration of a selective vasopressin V1 receptor antagonist prevented the stimulating action of vasopressin on novelty-induced grooming and its hypothermic effect. The ICV injection of a selective vasopressin V2 receptor antagonist failed to affect vasopressin-induced grooming and hypothermic effect. An increase in core temperature was observed in oxytocin-injected animals pretreated with the vasopressin V1 receptor antagonist. Furthermore, pretreatment with the antagonist did not affect grooming induced by oxytocin. These results suggest that enhancement of grooming behavior and influence on thermoregulation are differently regulated by central receptors for vasopressin and oxytocin.
在Wistar品系雄性大鼠中，研究了中枢血管升压素V1受体在血管升压素和催产素诱导的梳理行为中的作用。脑室内（ICV）注射血管升压素（3微克/5微升）可诱导体温过低，并增强新奇诱导的梳理行为。ICV注射催产素（3微克/5微升）也可诱导梳理行为增强，但不会引起体温过低。选择性血管升压素V1受体拮抗剂的中枢给药可阻止血管升压素对新奇诱导的梳理行为的刺激作用及其体温过低效应。ICV注射选择性血管升压素V2受体拮抗剂未能影响血管升压素诱导的梳理行为和体温过低效应。在用血管升压素V1受体拮抗剂预处理的催产素注射动物中观察到核心体温升高。此外，拮抗剂预处理不影响催产素诱导的梳理行为。这些结果表明，血管升压素和催产素的中枢受体对梳理行为的增强和体温调节的影响存在不同的调节方式。
