一种针对日本血吸虫（亚洲血吸虫）的疫苗：副肌球蛋白作为保护性免疫靶点的最新进展。

A vaccine against the Asian schistosome, Schistosoma japonicum: an update on paramyosin as a target of protective immunity.

作者信息

Kalinna B H, McManus D P

机构信息

Molecular Parasitology Unit, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, Bancroft Centre, Royal Brisbane Hospital, Australia.

出版信息

Int J Parasitol. 1997 Oct;27(10):1213-9. doi: 10.1016/s0020-7519(97)00119-7.

DOI:10.1016/s0020-7519(97)00119-7

PMID:9394192

Abstract

Paramyosin from parasitic worms of the genus Schistosoma has shown promise as a vaccine target and it is one of the candidates selected by WHO for the development of a vaccine against schistosomiasis. Here we discuss the literature of the past decade and report on different recombinant paramyosin constructs we are using in our laboratory to develop a vaccine against the Asian schistosoma, Schistosoma japonicum.

摘要

来自血吸虫属寄生蠕虫的副肌球蛋白已显示出作为疫苗靶点的潜力，它是世界卫生组织选定用于开发抗血吸虫病疫苗的候选物之一。在此，我们讨论过去十年的文献，并报告我们实验室正在使用的不同重组副肌球蛋白构建体，以开发针对亚洲血吸虫——日本血吸虫的疫苗。