Law M F, Deasy P B, McLaughlin J P, Gabriel S
Department of Pharmaceutics, Trinity College, University of Dublin, Ireland.
J Microencapsul. 1997 Nov-Dec;14(6):713-23. doi: 10.3109/02652049709006821.
Two commercial brands of microcrystalline cellulose, the widely used Avicel PH-101 and the newly available Pharmacel 101, were compared for aqueous extrusion-spheronization of a model mix with lactose. Based on the results of multi-level experiments employing pellet size analysis by sieving and sphericity determination by image analysis, Avicel was shown to be less adversely affected by variation in added water or speed of spheronization. Physicochemical testing of powder samples from both brands was carried out using laser particle sized analysis, density determinations, differential scanning calorimetry and X-ray diffraction studies. The results indicated that the improved ease of processing with Avicel may be related to its smaller particle size with less aggregates, improved flow, lower depolymerization temperature range and absence of traces of cellulose II in its cellulose I content.
对两种市售微晶纤维素品牌，即广泛使用的微晶纤维素PH-101和新推出的药用微晶纤维素101，进行了与乳糖的模型混合物的水相挤出滚圆比较。基于采用筛分法进行丸粒尺寸分析和图像分析法测定球度的多级实验结果，发现微晶纤维素受添加水量或滚圆速度变化的不利影响较小。使用激光粒度分析、密度测定、差示扫描量热法和X射线衍射研究对两个品牌的粉末样品进行了物理化学测试。结果表明，微晶纤维素加工便利性的提高可能与其较小的粒径、较少的聚集体、更好的流动性、较低的解聚温度范围以及纤维素I含量中不存在纤维素II痕迹有关。
