Yüksel N, Baykara T
Department of Pharmaceutical Technology, Faculty of Pharmacy, Ankara University, Turkey.
J Microencapsul. 1997 Nov-Dec;14(6):725-33. doi: 10.3109/02652049709006822.
Polymeric microspheres containing nicardipine hydrochloride (HCl) as a reference drug were prepared with the acrylic polymers Eudragit RS and L by the solvent evaporation method. Different concentrations of sucrose stearate as a droplet stabilizer were used. Sucrose stearate affected the diffusion rate of the solvent from the preliminary emulsion droplets to the outer phase for the formation of microspheres. Increasing concentrations of sucrose stearate in the formulations caused increasing porosity on the surface of the microspheres. However, a correlation between the concentrations of sucrose stearate and diameters of microspheres could not be assessed. From this point of view, during processing, applied stirring rate was important.
采用溶剂蒸发法，以丙烯酸聚合物Eudragit RS和L制备了含有盐酸尼卡地平（HCl）作为参比药物的聚合物微球。使用了不同浓度的蔗糖硬脂酸酯作为液滴稳定剂。蔗糖硬脂酸酯影响溶剂从初步乳液液滴扩散到外相以形成微球的速率。制剂中蔗糖硬脂酸酯浓度的增加导致微球表面孔隙率增加。然而，无法评估蔗糖硬脂酸酯浓度与微球直径之间的相关性。从这一角度来看，在加工过程中，施加的搅拌速率很重要。
