Gürsoy A, Senyücel B
Department of Pharmaceutical Technology, Faculty of Pharmacy, Marmara University, Haydarpaşa, Istanbul, Turkey.
J Microencapsul. 1997 Nov-Dec;14(6):769-76. doi: 10.3109/02652049709006827.
Neutral, (-) and (+) charged CF encapusulated liposome formulations prepared with EPC:Chol and DPPC:Chol lipids were investigated for their loading capacity, encapsulation % and release properties. CF amounts in the liposomes were estimated using derivative UV spectroscopy. Among the liposome formulations DPPC:Chol and EPC:Chol neutral formulations had a significantly higher loading capacity and slowest release rate compared with (-) and (+) charged liposomes. The derivative UV spectroscopy was found to be an easy and sensitive method for direct estimation of CF in liposomes.
用EPC:Chol和DPPC:Chol脂质制备的中性、带负电荷和带正电荷的CF包封脂质体制剂，对其载药量、包封率和释放特性进行了研究。使用导数紫外光谱法估算脂质体中的CF含量。在脂质体制剂中，与带负电荷和带正电荷的脂质体相比，DPPC:Chol和EPC:Chol中性制剂具有显著更高的载药量和最慢的释放速率。发现导数紫外光谱法是直接估算脂质体中CF的一种简便且灵敏的方法。
