Koda M, Okamura T, Kobashi T, Kawabe J, Ochi H, Yamada R, Hino M
Department of Radiology, Osaka City University Medical School.
Kaku Igaku. 1997 Sep;34(9):821-6.
To detect a primary neuroblastoma lesion and its metastases, 131I-MIBG scintigraphy was performed for a 24-year-old woman who had a high level of serum catecholamine. 131I-MIBG scintigrams showed high radioactivity in the left upper quadrant, pelvic bone, and vertebral bodies. A biopsy of the pelvic bone revealed metastasis from the neuroblastoma. After four chemotherapy courses, the accumulation of 131I-MIBG decreased after each course; however, scintigraphy performed after the last chemotherapy course showed focal mild uptake in the right sacroiliac. The presence of residual tumor in the sacroiliac was confirmed histologically. On the other hand, T1-weighted and T2-weighted MR images performed before the treatment showed low signal intensity and high signal intensity in the pelvic bone, respectively. After the fourth chemotherapy course, T2-weighted MR images showed low signal intensity in the pelvic bone; however, it was difficult to determinate whether it should improve. To assess the effect of treatment of neuroblastoma, 131I-MIBG scintigraphy was considered more useful than MRI.
为检测原发性神经母细胞瘤病灶及其转移灶，对一名血清儿茶酚胺水平较高的24岁女性进行了¹³¹I - MIBG闪烁扫描。¹³¹I - MIBG闪烁扫描显示左上腹、骨盆骨和椎体有高放射性。骨盆骨活检显示为神经母细胞瘤转移。经过四个化疗疗程后，每个疗程后¹³¹I - MIBG的聚集都有所减少；然而，最后一个化疗疗程后进行的闪烁扫描显示右骶髂关节有局灶性轻度摄取。组织学证实骶髂关节存在残留肿瘤。另一方面，治疗前的T1加权和T2加权磁共振图像分别显示骨盆骨为低信号强度和高信号强度。第四个化疗疗程后，T2加权磁共振图像显示骨盆骨为低信号强度；然而，很难确定其是否有所改善。为评估神经母细胞瘤的治疗效果，¹³¹I - MIBG闪烁扫描被认为比MRI更有用。
