Röhrborn G, Buckel U
Hum Genet. 1976 Jul 27;33(2):113-9. doi: 10.1007/BF00281885.
The potentiating effect of caffeine (1,3,7-trimethylxanthine) on chemically induced chromosome aberrations was studied in bone marrow cells of chinese hamsters, exposed to the alkylating agent cyclophosphamide. Four experimental series were performed: In the first two tests caffeine (200 mg/kg) or cyclophosphamide (40 mg/kg), respectively, were administered. A third and fourth test was performed with caffeine plus cyclophosphamide (200 + 40 mg/kg and 35 + 40 mg/kg, respectively) simultaneously. Aberrations induced by cyclophosphamide (40 mg/kg) were strongly potentiated by simultaneous application of caffeine (200 mg/kg) not only additively but even synergistically. This increase of aberrations cannot be found after injection of the lower dose of caffeine (35 mg/kg).
研究了咖啡因（1,3,7 - 三甲基黄嘌呤）对中国仓鼠骨髓细胞化学诱导染色体畸变的增强作用，这些细胞暴露于烷化剂环磷酰胺。进行了四个实验系列：在前两个试验中，分别给予咖啡因（200毫克/千克）或环磷酰胺（40毫克/千克）。第三个和第四个试验同时给予咖啡因加环磷酰胺（分别为200 + 40毫克/千克和35 + 40毫克/千克）。同时应用咖啡因（200毫克/千克）不仅以相加方式而且甚至以协同方式强烈增强了环磷酰胺（40毫克/千克）诱导的畸变。注射较低剂量的咖啡因（35毫克/千克）后未发现这种畸变增加。
