Lee G A, Hirst L W
Department of Surgery, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
Aust N Z J Ophthalmol. 1997 Nov;25(4):269-76. doi: 10.1111/j.1442-9071.1997.tb01514.x.
Ocular surface squamous neoplasia (OSSN) encompasses the conditions of simple dysplasia to carcinoma in situ to invasive squamous cell carcinoma. It has a high rate of recurrence after treatment and the potential to metastasize. The present retrospective study was aimed at further defining the characteristics and clinical course of OSSN.
With ethical approval, the records of all major pathology laboratories in Queensland were surveyed. Two hundred and eighty-eight cases were identified: 155 dysplasia, 71 carcinomas in situ and 62 invasive squamous cell carcinoma. The records were analysed and an attempt was made to contact and re-examine the patients.
Ocular surface squamous neoplasia occurs mainly in males (78.5%) with a mean age of 60.1 years (range 20-88 years). They present as irritation (40.1%) and are located usually at the limbus (87.8%). The majority of OSSN are treated by simple excision (87.5%), after which there is a high rate of recurrence (23.3%). The main predictors for recurrence include histological grade of the lesion, corneal location and larger size (> 2 mm).
Management of OSSN requires adequate excision and careful follow up to monitor any recurrence. As with other ultraviolet light-related conditions, preventative measures must remain the key to disease control.
眼表鳞状上皮病变（OSSN）涵盖了从单纯发育异常到原位癌再到浸润性鳞状细胞癌的一系列病症。其治疗后复发率高且有转移的可能。本回顾性研究旨在进一步明确OSSN的特征和临床病程。
经伦理批准，对昆士兰州所有主要病理实验室的记录进行了调查。共识别出288例病例：155例发育异常、71例原位癌和62例浸润性鳞状细胞癌。对记录进行了分析，并尝试联系并重新检查患者。
眼表鳞状上皮病变主要发生于男性（78.5%），平均年龄60.1岁（范围20 - 88岁）。症状表现为眼部刺激感（40.1%），病变通常位于角膜缘（87.8%）。大多数OSSN通过单纯切除术治疗（87.5%），术后复发率较高（23.3%）。复发的主要预测因素包括病变的组织学分级、角膜位置和较大尺寸（> 2 mm）。
OSSN的管理需要充分切除并仔细随访以监测任何复发情况。与其他与紫外线相关的病症一样，预防措施仍是疾病控制的关键。
