Scott D A
Enteric Diseases Program, Naval Medical Research Institute, Bethesda, Maryland 20852, USA.
J Infect Dis. 1997 Dec;176 Suppl 2:S183-8. doi: 10.1086/513791.
Campylobacter jejuni is one of the most common causes of diarrhea worldwide. The gastrointestinal manifestations of Campylobacter infection range from watery diarrhea to severe dysentery. Campylobacter infection has also been linked to the postinfectious sequelae of reactive arthritis and Guillain-Barré syndrome. Evidence from epidemiologic and volunteer studies suggests that development of a vaccine to prevent gastrointestinal disease and limit colonization is possible. Efforts to develop live attenuated or subunit vaccines are limited by the finite knowledge of Campylobacter pathogenesis and lack of a conserved protective antigen, respectively. An oral killed, whole-cell vaccine has been shown to be safe and effective in animal models and is currently being tested in phase I volunteer studies.
空肠弯曲菌是全球腹泻最常见的病因之一。空肠弯曲菌感染的胃肠道表现从水样腹泻到严重痢疾不等。空肠弯曲菌感染还与反应性关节炎和吉兰 - 巴雷综合征的感染后后遗症有关。流行病学和志愿者研究的证据表明，开发一种预防胃肠道疾病和限制定植的疫苗是有可能的。开发减毒活疫苗或亚单位疫苗的努力分别受到对空肠弯曲菌发病机制了解有限和缺乏保守保护性抗原的限制。一种口服灭活全细胞疫苗在动物模型中已显示出安全有效，目前正在I期志愿者研究中进行测试。
