Brun A, Abdulla M, Ihse I, Samuelsson B
Histochemistry. 1976 Apr 21;47(1):23-9. doi: 10.1007/BF00492990.
Uptake and localization of mercury was studied in rats orally intoxicated with inorganic mercury. By atomic absorption spectrophotometry large quantitative differences were found between test and control animals, particularly relating to blood, kidney and brain. By histochemical demonstration of heavy metals the uptake in the CNS was shown to occur particularly within the cytoplasm of large neurons in the cortex, pons and basal ganglia but also in other neurons, to some extent in the choroid plexus and the vessel walls, and least in the white matter. No lesions were detectable by light microscopy. The mercury was mostly in the methylated form, something that may be explained by gastrointestinal methylation by bacteria. A similar mechanism can be expected in human chronic inorganic mercury poisoning.
对经口摄入无机汞而中毒的大鼠体内汞的摄取与定位进行了研究。通过原子吸收分光光度法发现，试验组与对照组动物之间存在很大的定量差异，尤其是在血液、肾脏和大脑方面。通过重金属的组织化学显示，中枢神经系统中的摄取尤其发生在大脑皮层、脑桥和基底神经节的大神经元的细胞质内，但在其他神经元中也有摄取，在脉络丛和血管壁中有一定程度的摄取，而在白质中摄取最少。光学显微镜下未检测到病变。汞大多以甲基化形式存在，这可能是由细菌进行的胃肠道甲基化所解释的。在人类慢性无机汞中毒中可能预期有类似的机制。
