Rein A J, Beeri E
Division of Pediatric Cardiology, Hadassah University Hospital, Jerusalem, Israel.
Isr J Med Sci. 1997 Oct;33(10):649-53.
The increasing interest in arterial duct flow patterns in the fetus warrants the establishment of an accurate range of normal flow parameters throughout gestation. We therefore undertook a prospective echocardiographic study of 181 normal fetuses from the 16th to the 40th week of gestation. Adequate Doppler interrogation of the duct was obtained in 71% of the fetuses examined. Peak gradient, mean gradient and flow velocity integral in systole and diastole were digitized. The peak systolic gradient throughout pregnancy measured 2.7 +/- 1.4 mmHg with a slight tendency to increase with gestational age (r = 0.58). The peak ratio, defined as peak systolic gradient divided by peak diastolic gradient (28.1 +/- 14.9), did not vary significantly with gestational age. This time-independent index complements peak systolic flow in the assessment of normal and abnormal ductal flow. The definition of the normal range for ductal flow parameters, based on this relatively large fetal population, should facilitate the accurate diagnosis of fetal duct constriction.
对胎儿动脉导管血流模式日益增长的兴趣使得有必要确定整个孕期正常血流参数的准确范围。因此，我们对181例孕16至40周的正常胎儿进行了一项前瞻性超声心动图研究。在71%接受检查的胎儿中获得了对导管的充分多普勒检测。对收缩期和舒张期的峰值梯度、平均梯度和流速积分进行了数字化处理。整个孕期的收缩期峰值梯度为2.7±1.4 mmHg，有随孕周略有增加的趋势（r = 0.58）。峰值比定义为收缩期峰值梯度除以舒张期峰值梯度（28.1±14.9），随孕周无显著变化。这个与时间无关的指标在评估正常和异常导管血流时补充了收缩期峰值血流。基于这一相对较大的胎儿群体对导管血流参数正常范围的定义，应有助于准确诊断胎儿导管狭窄。
