Ball V A, Righi P D, Tejada E, Radpour S, Pavelic Z P, Gluckman J L
Department of Otolaryngology-Head and Neck Surgery, Indiana University Medical Center, Indianpolis, USA.
Ear Nose Throat J. 1997 Nov;76(11):818-23.
Local and regional recurrence is the principal reason for treatment failure in squamous cell carcinoma (SCC) of the head and neck. The conventional method of evaluating surgical margins for cellular atypia does not always predict risk of local recurrence accurately. Immunostaining of surgical margins for tumor markers may provide a more precise evaluation of risk of local recurrence. Paraffin-embedded tissue blocks of surgical margins from 24 patients with oral cavity and oropharyngeal squamous cell carcinoma were immunostained for p53 protein. Fifty-eight percent of the patients had at least one margin stain positive for p53, including eight of ten patients whose SCC recurred locally. The sample odds ratio test predicted a 5.333 times higher chance of local recurrence with at least one p53 positive surgical margin. The implications of these results for patient management and further investigations will be discussed.
局部和区域复发是头颈部鳞状细胞癌（SCC）治疗失败的主要原因。评估手术切缘细胞异型性的传统方法并不能总是准确预测局部复发风险。对手术切缘进行肿瘤标志物免疫染色可能会更精确地评估局部复发风险。对24例口腔和口咽鳞状细胞癌患者手术切缘的石蜡包埋组织块进行p53蛋白免疫染色。58%的患者至少有一个手术切缘p53染色呈阳性，其中10例局部复发的患者中有8例。样本比值比检验预测，至少有一个p53阳性手术切缘时，局部复发的可能性要高5.333倍。将讨论这些结果对患者管理和进一步研究的意义。
